Thursday, January 31, 2013

DEP Awards Energy-Efficiency, Pollution-Prevention Grants to 32 Small Businesses

The Department of Environmental Protection has awarded $239,809 in grants to help 32 small businesses across Pennsylvania invest in energy-efficiency or pollution-prevention projects.

?Becoming energy-efficient can involve an initial up-front investment that will be proportionally higher for small businesses,? DEP Secretary Mike Krancer said. ?The investment will pay for itself and more over time, but this program makes that transition more doable for Pennsylvania?s small business owners.?

Pennsylvania?s Small Business Advantage Grant program, funded through the Hazardous Sites Cleanup Act, helps businesses with 100 or fewer employees. It provides 50-percent matching reimbursement grants of up to $9,500 to implement projects that will save 25 percent annually in pollution-prevention or energy-related costs. Since 2004, the program has invested $7.25 million in 1,720 small businesses statewide.

Of the $1 million in grants budgeted for the current fiscal year, this is the second of three announcements of selected grantees. The 32 new grants will create $812,987 of private-sector investment in small businesses.

Examples of eligible projects include high-efficiency HVAC and insulation upgrades, high-efficiency lighting to save energy, installation of energy-efficient heat pumps and new auxiliary power units that help large trucks reduce time spent with idling engines.

For more information about the Small Business Advantage Grant program, contact DEP?s Office of the Small Business Ombudsman at 717-772-8909 or via email at epadvantagegrant@pa.gov.

The information above provided by the Department of Environmental Protection.

Source: http://feedproxy.google.com/~r/fox43/jndg/~3/F0EBMga7gQQ/

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Fla. governor wants $1.2 billion more for schools

TALLAHASSEE, Fla. (AP) -- Florida Gov. Rick Scott will ask for a $1.2 billion boost in spending on public schools in the coming year, a move that could set up a clash with the Republican-controlled Legislature but could boost his bid for re-election.

Scott revealed the figure when he outlined his top spending priorities during The Associated Press' 19th annual planning meeting on Wednesday.

His announcement comes a day before the Republican governor is expected to make his 2013 budget recommendations to state legislators. Scott will give additional details on his budget proposal, although it is unlikely that Scott will provide a definitive answer on whether he supports accepting federal aid to expand Medicaid.

The total amount of money that Scott plans to seek for public schools includes his previously announced pitch to give every teacher in the state a $2,500 pay raise.

Scott ? who just two years ago had recommended a cut in education ? said that his proposal would boost per-student spending by roughly 6.5 percent.

"Investing in our teachers and in our education system is the key to our state's continued economic growth," Scott said. "We made the hard choices to recover and get back on track ? now we must make the smart choices to invest in Florida's future."

Some Democrats called Scott's recommendation an "epiphany" that may be more about his 2014 re-election bid. Scott has battled low poll numbers for most of his time in office.

"He's finally admitting that I was wrong to try to starve education," said Sen. Chris Smith, D-Fort Lauderdale.

A breakdown of Scott's schools proposal shows that some of the $1.2 billion won't necessarily make an impact in the classroom. His recommendations include a nearly $300 million payment into the state pension plan on behalf of teachers. Scott's recommendation also includes a $100 million "technology initiative" as well as the money needed to cover increased school enrollment.

It's unclear, however, whether Scott's fellow Republicans will approve a budget that includes his spending priorities. Legislative leaders have already said they are uneasy with an across-the-board pay raise for teacher salaries. But they also said that while the economy is improving the state does not have an unlimited budget surplus.

"We do have more revenue, our budget surplus is breathing room," House Speaker Will Weatherford said. "It's not enough to put your feet up on the couch."

Scott is expected to announce on Thursday spending reductions in some areas of state spending, including nearly $100 million in savings realized from changes in state contracts, the elimination of nearly 932 positions by closing offices, shedding vacant state jobs and reorganizing parts of state government.

But the governor refused to say much on what may be the biggest budget question of the 2013 session: Will the state of Florida accept billions in federal aid to expand Medicaid coverage?

Under President Barack Obama's health care law, Washington would pay 100 percent of the costs of expanding Medicaid from 2014 to 2016. Between 2017 and 2020, the federal share would decrease to 90 percent and the states' contribution would rise in stages to 10 percent, and that's where it would stay.

The law calls for states in 2014 to expand eligibility of Medicaid to those making up to 133 percent of the poverty level, or $29,326 for a family of four in Florida. The changes would also require adding people who are below the poverty level but not eligible for Medicaid, such as childless adults.

The U.S. Supreme Court ruled last summer that expansion of Medicaid is not mandatory and that states can opt out if they choose.

Scott said that there are still questions that need to be answered by federal authorities before he can render a verdict on Medicaid expansion ? hinting that he is unlikely to address it in the budget recommendations he will roll out.

The two Republican leaders of the Legislature said they are still undecided about the expansion.

But Weatherford told reporters and editors, however, that state lawmakers are ready to render a final verdict on expansion with or without the governor's input by sometime in March.

"We certainly care what the governor thinks," Weatherford said. "It would have an impact. But we're not waiting on him to tell us what to do in this regard."

Follow Gary Fineout on Twitter: http://twitter.com/fineout

Source: http://news.yahoo.com/fla-governor-wants-1-2-214619429.html

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WTCC: STR tendr? dos coches en el campeonato 2013.

El equipo brit?nico Special Tuning Racing (STR) est? trabajando para estar en la parrilla de este a?o con dos SEAT Le?n WTCC, con las ?ltimas mejoras de SEAT Sport para la temporada 2013 del WTCC.

El equipo tom? parte en su primera temporada completa como independiente en 2012 despu?s de abandonar el Campeonato Brit?nico de Turismos. El equipo comenz? el a?o con Darryl O'Young y el brit?nico Tom Boardman en sus dos SEAT.?

El equipo ten?a un coche actualizado a las ?ltimas especificaciones para la primera ronda en Monza para O'Young, con el segundo coche a la espera de recibir el motor de SEAT Sport ORECA desarrollada y otras actualizaciones en Portugal.?

El plan del equipo es volver a la parrilla de este a?o, con las ?ltimas actualizaciones de SEAT en sus dos Le?n, con el apoyo t?cnico y de ingenier?a de SEAT Sport.?


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Source: http://www.seatfansclub.com/2013/01/special-tuning-racing-tendra-dos-coches.html

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CSN: Peavy says pressure got to White Sox in '12

Despite all the days they were in first place in 2012, what everyone will remember most about the Chicago White Sox last season was their September collapse, when they went 4-11 in the final 15 games.
?
Their self-destruction earned them a seat on the couch for the playoffs--as well as a thank you card from the Detroit Tigers, who ended up winning the Central Division by three games.

What happened down the stretch?

Jake Peavy knows. It was the pressure.

Did it get to them?

?There's no doubt,? Peavy said in an interview with Comcast SportsNet. ?I think you could sense over the last few months that we weren't playing the best in the world, and you expected at that point in time that when you're in first place going into September you can't play with this, ?We've got nothing to lose attitude.? We do. We've got everything to lose, and that pressure takes that freeness away from you when you're expected to perform. I think us as a whole, I think we all have to take responsibility. It just didn't work out.?

You can point to the White Sox 6-12 record against the Tigers and Royals as a main reason for their demise. Both opponents consistently put the heat on the White Sox, and Robin Ventura?s team kept flaming out.

They had a roster filled with post-season veterans like Peavy, Paul Konerko, A.J. Pierzynski and Kevin Youkilis, but also many rookies and pennant race novices who were sniffing the playoffs for the very first time -- and it showed in the results.

?I think you saw the inexperience. I thought you saw a team that had been there in Detroit catching us, and a team trying to get there with a lot of new faces and a lot of meshing to do,? Peavy said. ?I think you saw that when things got on the line and we were the team to beat there, being in first place down the stretch and that pressure, you feel the immaturity as a club as a whole. I?m not just saying the young guys. I?m talking about myself, the Adam Dunn?s, the Paul Konerko?s. That?s our job to keep everyone calm and keep us holding on.?

Nothing can prepare you for those pressure-packed games but actually playing in them; to feel the emotions, to celebrate the wins, or in the White Sox case -- to stomach the losses.

?People talk about how you learn more in defeat than you do in winning. That's never more true than our case. That learning experience for every one one of us personally is invaluable,? Peavy said. ?There will be a bigger hunger, a bigger desire going into this year and getting into that situation again. There will be more of a peace and more of a ?I've been there and I know what it takes to get this thing done.??

When Jake takes the field for his first start in 2013, someone familiar with his thinking truly won?t believe it.

He was convinced this wouldn?t happen. He was sure he?d be in retirement by then.

Who had these thoughts?

Peavy did.

?I really felt like last year was going to be it for me,? Peavy revealed.

Going into the 2012 season, Peavy was almost two years removed from experimental surgery that reattached a tendon to his pitching shoulder. There was progress, but he was nowhere close to the same pitcher he was in 2007 when he won the Cy Young Award. ?

In 2010, he went 7-6 with a 4.63 ERA. In 2011, the results were a tick worse: 7-7 with a 4.92 ERA.

So when Peavy arrived in Arizona for spring training last year, he was prepared for it to be his final season. He questioned whether he?d ever be able to dominate again, and he certainly never thought he?d be in a position to receive the 2-year, $29 million contract he signed with the White Sox last October.

?No, I didn't. I can honestly tell you that I didn't,? Peavy said. ?I'm so thankful and so blessed to be sitting here today, but I swear to you that when I had that first surgery of that kind -- experimental, ground-breaking stuff -- no one really knew what to expect. Then trying to come back in the latter part of 2011 and just not feeling anywhere close to how I felt in previous years, I really felt like last year was going to be it.?

But to Peavy?s surprise, he was on the verge of a major breakthrough. His shoulder was fully healed. His body was finally in sync. He ranked in the top 10 in the American League in strikeouts and ERA. Even more impressive: he pitched 219 innings, fifth most in the A-L and his highest total since winning the Cy Young Award.

?I was going to grind it out and make sure there was no leaf left unturned. That I can do all that I could do,? Peavy said. ?Fortunately, things turned last winter and I was able to have that kind of year. I feel so blessed because I do love the game of baseball, and I do love getting to play, and I hope to play as long as I can.?

A free agent after last season, Peavy could have tested the open market, and probably would have collected a whole lot more than the 2-year, $29 million deal he received from the White Sox. Zack Greinke signed a 6-year, $147 million contract, Anibal Sanchez got 5 years, $80 million, Edwin Jackson 4 years, $52 million.

Peavy has no regrets.

?I was excited we could do something that worked for both sides. [$29 million] was a fair number. When both sides give a little bit, I think it works out well. You saw all the free agent contracts this winter. We knew that going in. Baseball is in a very good state financially and we?re excited. But I wasn?t after that.?

What Peavy wanted was another chance with the White Sox, a team he feels is ready to take the next step.

?I found a home here and it?s a place I?m comfortable. It?s something where I feel I still have more to give to the franchise and to my teammates. I don?t feel like I owed the White Sox anything, but I do feel like for me personally and team-wise there's unfinished business here.?

Watch Chuck Garfien's interview with Jake Peavy on SportsNet Central tonight at 6:30pm, 10:00pm and 12:00am.

Source: http://www.csnchicago.com/blog/white-sox-talk/peavy-says-pressure-got-white-sox

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Thursday, January 24, 2013

Total Recall: Anthology Movies

86%

The Directors: Olivier Assayas, Fr?d?ric Auburtin, Emmanuel Benbihy, Gurinder Chadha, Sylvain Chomet, Ethan Coen, Joel Coen, Isabel Coixet, Wes Craven, Alfonso Cuar?n, G?rard Depardieu, Christopher Doyle, Richard LaGravenese, Vincenzo Natali, Alexander Payne, Bruno Podalyd?s, Walter Salles, Oliver Schmitz, Nobuhiro Suwa, Daniela Thomas, Tom Tykwer, Gus Van Sant

The Big Idea: As you've probably already inferred from its title, Paris, je t'aime is all about the City of Light -- and whatever you think about the movie itself, let's say this much for it: With 18 segments and more than 20 directors wrapped into its two-hour running time, this is one anthology that takes the "short films" part of "collection of short films" seriously. With so many disparate talents jostling for attention, Paris probably should have been a disjointed mess, but according to most critics, it was quite the opposite -- as Owen Gleiberman put it for Entertainment Weekly, "Anthology films usually work better in theory than execution, but this feature parade of shorts is a blithe, worldly, and enchanting exception."

Source: http://www.rottentomatoes.com/m/1926709/news/1926709/

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Wednesday, January 23, 2013

Video: Was Obama?s address an olive branch to Iran?

'Getting worse': Egypt's gays fear crackdown

??CAIRO, Egypt -- The 2011 revolution which ousted Hosni Mubarak left many of Egypt's gays and lesbians hoping sexual freedom was on the horizon. But today, many fear a government crackdown is only a matter of time.

Source: http://video.msnbc.msn.com/hardball/50553865/

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Novel gene-searching software improves accuracy in disease studies

Jan. 22, 2013 ? A novel software tool, developed at The Children's Hospital of Philadelphia, streamlines the detection of disease-causing genetic changes through more sensitive detection methods and by automatically correcting for variations that reduce the accuracy of results in conventional software. The software, called ParseCNV, is freely available to the scientific-academic community, and significantly advances the identification of gene variants associated with genetic diseases.

"The algorithm we developed detects copy number variation associations with a higher level of accuracy than that available in existing software," said the lead inventor of ParseCNV, Joseph T. Glessner, of the Center for Applied Genomics at The Children's Hospital of Philadelphia. "By automatically correcting for variations in the length of deleted or duplicated DNA sequences from one individual to another, ParseCNV produces high-quality, highly replicable results for researchers studying genetic contributions to disease."

Glessner is the lead author of a study describing ParseCNV, published Jan. 4 in Nucleic Acids Research.

Copy number variations (CNVs) are particular sequences of DNA, ranging in length from 1000 to millions of nucleotide bases, which may be deleted or duplicated. While in any given region of a person's DNA, CNVs are very rare, everyone's genome has CNVs, many of which play important roles in causing or influencing disease.

In searching for associations between CNVs and diseases, researchers typically perform case-control studies, comparing DNA samples from patients to DNA from healthy individuals, looking for telltale differences in how CNVs are overrepresented or underrepresented.

CNVs, however, occur in multiple types among individuals, said senior author Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia. "One person may have a 60-kilobase deletion, while another may have a 100-kilobase deletion; that may determine the difference between a healthy state versus disease. Many CNV detection softwares may misread the boundary of a CNV region, which could lead to a misclassification and result in false-positive or false-negative associations."

ParseCNV is designed with built-in corrections to adjust for these size variations and other red flags that confound results. Using polymerase chain reaction testing to validate the initial findings, the study team determined that the software had called 90 percent of the CNVs accurately -- a better rate than conventional CNV association softwares, which typically produce validation rates that are notably lower.

The authors say the program's comprehensive design, statistical capabilities, and quality-control features lend it versatility, applicable not just to case-control studies, but also to family studies, and quantitative analyses of continuous traits, such as obesity or height.

Glessner says the Center for Applied Genomics team will continue to refine ParseCNV's features as CNV research progresses. Hakonarson adds that the ParseCNV algorithm will advance genomic diagnostics: "It is likely to play a future key role as a research tool in improving detection of CNV association in individual patients enrolled in disease studies -- perhaps through an initial diagnostic screen, to be followed up with a CLIA-certified laboratory test."

An Institutional Development Award from The Children's Hospital of Philadelphia supported this research, along with the Cotswold Foundation and a donation from Adele and Daniel Kubert. The third co-author, also from the Children's Hospital genome center, was Jin Li.

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The above story is reprinted from materials provided by Children's Hospital of Philadelphia, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. T. Glessner, J. Li, H. Hakonarson. ParseCNV integrative copy number variation association software with quality tracking. Nucleic Acids Research, 2013; DOI: 10.1093/nar/gks1346

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/q0NoOFgZkiE/130122162130.htm

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The Horse | UK College of Agriculture Weather Center Warns of ...

UK College of Agriculture Weather Center Warns of Livestock Cold Stress

The average horse, with a lower activity level, should eat between 1.5 and 2% of his body weight in feed per day to maintain weight. But that feed requirement increases in the winter, as the horse uses more calories to keep warm.

Photo: Megan Arszman, TheHorse.com Web Producer

Agricultural meteorologists from the University of Kentucky (UK) College of Agriculture warned that arctic cold has settled into the Bluegrass State.

"This is much colder air than we have seen the past couple of winters," said Tom Priddy, UK agricultural meteorologist. "An arctic air mass, coupled with north winds, will create wind chills in the single digits."

Priddy said the combination of cold air and high winds could put most parts of Kentucky into periods of dangerous and emergency categories for livestock cold stress.

Livestock producers should ensure animals have adequate shelter, water, dry bedding, and feed to endure this cold spell, and pet owners should bring pets indoors. UK livestock specialists said animals have a higher energy requirement in the colder months, so producers should have high-quality grains and forages on hand to meet their needs.

According to scientists in the College of Agriculture, as the external temperature declines, the maintenance energy value for an animal increases to maintain core body temperature. Animals maintain core body temperature by increasing their metabolism, resulting in greater heat production, as well as other heat conservation strategies such as reducing blood flow to the extremities, shivering, and increased intake.

Both external and internal insulation influence an animal's ability to handle very cold temperatures. External insulation is basically the depth and thickness of the hair coat. The hair coat acts as insulation similar to home attic insulation that traps air, enhancing the insulating value. If the hair is wet and full of mud, air is excluded, reducing the insulating value and increasing heat loss from the skin to the environment. The hair coat's density and whether it is wet or dry impacts the wind chill temperatures at which cold stress is considered mild, moderate, or severe. As little as 0.1 inch of rain can immediately impact cold stress severity by matting the hair down and reducing its insulating ability. Acclimation time, coat thickness, fat cover, and other factors will also influence the degree of cold stress that animals experience.

The average horse, with a lower activity level, should eat between 1.5 and 2% of his body weight in feed per day to maintain weight. UK equine specialist Bob Coleman, PhD, said that feed requirement increases in the winter, as the horse uses more calories to keep warm. He recommended providing extra hay and making sure horses have shelter to get out of windy, damp weather. He said it's also very important for horses to have access to clean, unfrozen water.

Coleman said horse owners can separate animals according to body condition score and supplement them accordingly or offer them higher quality forage if available.

Source: edited College of Agriculture news release. For more information, contact Tom Priddy or Matt Dixon, 859/257-3000, ext. 245, or Bob Coleman, 859/257-9451.

Aimee Nielson is an agricultural communications specialist within UK's College of Agriculture.


Want more articles like this? Sign up for the Bluegrass Equine Digest e-Newsletter.

More information on Gluck Equine Research Center and UK Ag Equine Programs.

Source: http://www.thehorse.com/media/31245

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Great Tools Project Managers Can Use to Improve ... - DefinedLogic

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Source: http://www.definedlogic.com/2013/01/great-tools-project-managers-can-use-to-improve-project-communications/

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Israelis expected to return Netanyahu to office

Israeli Prime Minister Benjamin Netanyahu casts his ballot?at a polling station in Jerusalem, Tuesday, Jan. 22, 2013.?Israelis headed to polling stations Tuesday to cast votes in a parliamentary election expected to return Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles. (AP Photo/Uriel Sinai, Pool)

Israeli Prime Minister Benjamin Netanyahu casts his ballot?at a polling station in Jerusalem, Tuesday, Jan. 22, 2013.?Israelis headed to polling stations Tuesday to cast votes in a parliamentary election expected to return Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles. (AP Photo/Uriel Sinai, Pool)

Ultra-Orthodox Jews arrive to vote in legislative elections, at a school in Bnie Brak, Israel, Tuesday, Jan. 22, 2013. Israelis began trickling into polling stations Tuesday morning to cast their votes in a parliamentary election expected to return Prime Minister Benjamin Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles.(AP Photo/Oded Balilty)

Naftali Bennett, head of Israel's Jewish Home party, left, waves to a crowd as he leaves a polling station after voting in Raanana, Israel, Tuesday, Jan. 22, 2013. Israelis began trickling into polling stations Tuesday morning to cast their votes in a parliamentary election expected to return Prime Minister Benjamin Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles. (AP Photo/Ariel Schalit)

Naftali Bennett, head of Israel's Jewish Home party, left, waves to journalists after voting in parliamentary elections with his wife Gilat, at a polling station in Raanana, Israel, Tuesday, Jan. 22, 2013. Israelis began trickling into polling stations Tuesday morning to cast their votes in a parliamentary election expected to return Prime Minister Benjamin Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles. (AP Photo/Ariel Schalit)

Ultra-orthodox Jew votes in Bnie Brak, Israel, during legislative elections Tuesday, Jan. 22, 2013. Israelis began trickling into polling stations Tuesday morning to cast their votes in a parliamentary election expected to return Prime Minister Benjamin Netanyahu to office despite years of stalled peacemaking with the Palestinians and mounting economic troubles. Polls indicate about a dozen of 32 parties competing in Tuesday's election have a chance of winning seats in the 120-member parliament. Most parties fall either into the right-wing-religious or center-left camp, and surveys indicate hard-line and ultra-Orthodox Jewish parties will command a majority. (AP Photo/Oded Balilty)

(AP) ? Israelis voted Tuesday in an election likely to keep hard-line Prime Minister Benjamin Netanyahu at the helm of government for a third term despite a turbulent record: no peace process with Palestinians, growing diplomatic isolation and signs of economic trouble ahead.

The balloting capped a lackluster three-month campaign that was expected to leave Netanyahu at the helm of a coalition dominated by hard-liners opposed to concessions that could bring Palestinians back to the negotiating table.

The outcome, if opinion polls are accurate, was expected to put Israel on the path to continued deadlock in peace efforts with the Palestinians and further run-ins with the international community, including its key ally, the United States.

Voters appeared to be overlooking Netanyahu's record over the past four years, and the conflict with the Palestinians, long the defining issue in Israeli politics, was largely absent from the campaign. That reflected the widespread Israeli belief that a peace deal is impossible and the dovish opposition's failure to unite behind a viable alternative candidate.

Netanyahu is widely seen, even by some opponents, as the man best suited to lead the country at a turbulent time. He has maintained a lead with a message that the country needs a tough-minded and experienced leader to face down dangers including the Iranian nuclear program, potentially loose chemical weapons in Syria and the rise of fundamentalist Islam in Egypt and other Arab countries amid the Arab Spring.

The results were not assured. Election officials reported relatively high turnout compared to previous years, boosted by sunny, spring-like weather. A heavy turnout could favor Netanyahu's opponents, whose voters tend to have a lower participation rate than the highly motivated hard-liners. In addition, opinion polls have often been inaccurate in the past.

Netanyahu, 63, was smiling when he arrived early at a heavily secured polling station in Jerusalem with his wife, Sara, and two sons, both first-time voters. After voting, the prime minister told reporters that a flood of ballots for his list "is good for Israel."

Many opponents have largely yielded the security issue to Netanyahu and instead campaigned on economic issues, such as the country's high cost of living and its much-maligned custom of giving generous handouts and draft exemptions to the ultra-Orthodox Jewish minority. While Israel's economy has remained on solid footing, Netanyahu's government has run up a huge deficit that could result in steep budget cuts in the coming months.

Only one major contender, former Foreign Minister Tzipi Livni, has campaigned on a platform centered on the need to restart peace talks and reach a deal with the Palestinians. Her new Movement party was expected to emerge as a midsize faction.

Livni implored voters to think about the "big decisions" at hand. "The vote I have cast includes the hopes of all the people who don't want four more years of Netanyahu and this government, for everyone who is worried about justice and Israel's isolation," she said

In the weeks running up to Tuesday's vote, opinion polls have universally forecast Netanyahu's Likud-Yisrael Beitenu emerging as the largest single bloc, controlling roughly one-quarter of parliament's 120 seats and in a strong position to form a new majority coalition. Along with other nationalist and religious parties that traditionally support him, Netanyahu is expected to be able to easily secure a majority of more than 61 seats.

Should the right wing and religious parties somehow fail to muster a majority, there will be a mad scramble on the center-left to try to form a coalition on their own.

Under such a shocking result, the prime minister could end up being Labor Party leader Shelly Yachimovich, a former radio journalist who once backed Israel's Communist party. Yachimovich, campaigning on a promise to narrow the gap between rich and poor, has already said she will not sit in a Netanyahu government. But such an outcome appeared unlikely.

In all, 32 parties were running for representation in parliament. Israel has historically had multiparty governments because no party has ever won an outright majority in the country's 64-year history. Polls close at 10 p.m. local time (3 p.m. EST, 2000 GMT), with exit poll results available immediately and official results trickling in throughout the night.

In a modern-day twist, many Israelis advertised their voting choice by photographing their completed ballot and uploading it to Facebook.

If victorious, Netanyahu is expected to explore reaching across the aisle to bring in at least one of the more centrist parties opposing him, both to reduce his reliance on the hard-liners and to present a more palatable face to the outside world.

But it remains unclear whether he would be able to do so, since it would require concessions on key issues, either economically or diplomatically, that would alienate his core supporters.

One potential centrist partner would be political newcomer Yair Lapid, a former TV talk show host, who has gained popularity by taking aim at the preferential treatment given to the ultra-Orthodox. Lapid has said, however, he will not be a "fig leaf" for an extremist government.

In any case, a shift by Netanyahu away from his tough line toward the Palestinians appears unlikely. Netanyahu himself has only grudgingly voiced conditional support for a Palestinian state, and his own party is now dominated by hard-liners who oppose even this.

A likely coalition partner, Naftali Bennett of the surging Jewish Home Party, has even called for annexing large parts of the West Bank, the core of any future Palestinian state. Bennett's party has siphoned off many Netanyahu supporters who believe the prime minister has grown soft.

Motti Saban, a 25-year-old student in Jerusalem, said he would vote for Jewish Home.

"We are right-wing and we want to see a parliament that is more right wing than now," Saban said. "Social issues affect us all, but I won't give up Jerusalem, that's more important," Saban said.

Up to one-sixth of the incoming legislature is expected to be settlers who advocate holding on to captured land the Palestinians want for a future state.

Netanyahu has won praise at home for drawing the world's attention to Iran's suspect nuclear program and for keeping the economy on solid ground at a time of global turmoil. Tehran denies it is seeking to develop atomic weapons as alleged by Israel, the U.S. and allies.

But internationally, he has repeatedly clashed with his allies over his handling of the peace process. Peace talks with the Palestinians have remained deadlocked throughout his term, in large part because of his continued construction of Jewish settlements in the West Bank and east Jerusalem.

The Palestinians claim both areas, captured by Israel in the 1967 Mideast war, as part of their future state and refuse to negotiate while settlement construction takes place.

Netanyahu has said talks should resume without preconditions. The continued construction, along with Netanyahu's insistence that Israel retain all of east Jerusalem and parts of the West Bank, has led the Palestinians to conclude it is futile to even negotiate.

The international community has shown increasing impatience with Netanyahu. In November, the U.N. General Assembly overwhelmingly voted in favor of establishing a Palestinian state in all of the territories captured by Israel in 1967 ? the West Bank, Gaza Strip and east Jerusalem.

The newly re-elected President Barack Obama has had a rocky relationship with Netanyahu and the two men could find themselves on a collision course in their new terms.

In London Tuesday, British Foreign Secretary William Hague said Obama must now make the Middle East peace process his top priority, warning "we are approaching the last chance to bring about such a solution."

Critics warn that Israelis are ignoring the issue at their peril. First, signs are growing that the current lull in violence may be temporary ? both because the Palestinian street is getting frustrated and because Mahmoud Abbas' Palestinian Authority may cease the security cooperation that even Israeli officials have credited with the halt in fighting.

Beyond that, a persistent chorus warns that the status quo is ultimately self-defeating for Israel because the default outcome is a single entity in the Holy Land ? comprising Israel and all the areas it seized in the 1967 war. Based on current birthrates, most experts believe that Arabs would soon be the majority.

Palestinian officials say that Abbas has repeatedly warned Israeli visitors in recent months that Israel could end up like an "apartheid-style" state with a Jewish minority ruling over a disenfranchised Arab majority. At that point, the Arabs would turn their struggle away from independence and instead seek equality in a single state.

The rival Hamas government in Gaza condemned Netanyahu.

"It's clear that the election trends are moving from an extremist government toward more extreme government, which requires us as Palestinians, Arabs and Muslims to draw a strategy to confront the Zionist rising extremism," Hamas' prime minister, Ismail Haniyeh said.

___

Associated Press writers Amy Teibel and Diaa Hadid in Jerusalem and Cassandra Vinograd in London contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-22-Israel-Election/id-3a2353d9d67d49ce81b35fe2634003e5

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Tuesday, January 22, 2013

Emergency room redux for many patients after hospitalization

Jan. 22, 2013 ? After a hospitalization, patients face many challenges as they transition home. A new study of this vulnerable period published by Yale School of Medicine researchers in JAMA found that a substantial number of patients return to the emergency department soon after leaving the hospital, and, while such patients are not usually readmitted, the study raises concerns that many more patients require acute medical care after hospital discharge than previously recognized.

A hospital's readmission rate is a marker of hospital quality of care and the success of patient transitions to outpatient care. However, hospital readmission rates may not tell the whole story.

"It's frustrating to see people ending up back in the emergency room so soon after leaving the hospital," said the study's lead author Dr. Anita Vashi, a Robert Wood Johnson clinical scholar at Yale. "It makes me wonder about the cause. Are we not educating them well enough about how to safely transition home? Or do we not have capacity in the system for their care team to coordinate follow-up care if they have a complication? Either way, care that is fragmented in this manner can lead to conflicting recommendations, medication errors, distress, and higher costs."

Vashi and her team studied over five million patients who were discharged from acute care hospitals across three states -- California, Florida, and Nebraska -- in 2008-2009. Nearly 18% of hospitalized patients returned to either the emergency room or were readmitted within 30 days following discharge. Medicare beneficiaries had even higher rates. Visits to the emergency room, which are not currently measured by hospital readmission rates, accounted for nearly 40% of all visits back to the hospital within 30 days after discharge.

"The big question is how many of these emergency room visits could have been avoided by tightening up our healthcare system, and ensuring close collaboration and communication between patients and their health providers inside and outside the hospital," said senior author Dr. Cary Gross, associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) center at Yale. "Future work should focus on identifying how to decrease the need for patients to seek emergency room care right after they leave the hospital."

Conditions with the highest emergency room rates were related to mental health, drug and alcohol abuse, and prostate issues. "High and varying rates of emergency room utilization suggest there is potential to improve care coordination and acute care delivery," said Vashi. "If we don't expand our view of post-acute care from readmissions to include emergency room visits, we will severely underestimate patient needs and system resources required to care tor them."

Other study authors include Dr. Justin P. Fox, Dr. Brendan G. Carr, Dr. Gail D'Onofrio, Dr. Jesse M. Pines, and Dr. Joseph S. Ross.

The study was supported by the Robert Wood Johnson Foundation; the National Institute on Aging (Ross); the American Federation for Aging Research through the Paul B. Beeson Career Development Award Program (Ross); and a career development award to Carr K08 AG032886 from the Agency for Healthcare Research and Quality.

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The above story is reprinted from materials provided by Yale University.

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Journal Reference:

  1. Anita A. Vashi et al. Use of Hospital-Based Acute Care Among Patients Recently Discharged From the Hospital. JAMA, 2013 DOI: 10.1001/jama.2012.216219

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/x7WlIarSgO8/130122162327.htm

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Enzyme helps cancer cells avoid genetic instability

Jan. 21, 2013 ? Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.

The BRCA1 protein helps to mend double-strand DNA breaks by promoting homologous recombination. Without it, cells can amass broken, jumbled, and fused chromosomes, which may cause them to stop growing or die. Although cells lacking BRCA1 seem like they should be vulnerable, loss of the protein instead seems to boost abnormal growth.

Recent studies have shown that cells lacking BRCA1 compensate by cutting back on 53BP1. This protein helps orchestrate a different DNA repair mechanism, nonhomologous end joining (NHEJ), and it thwarts a key step in homologous recombination. Researchers think that, in cells without BRCA1, 53BP1 spurs excessive NHEJ that can cause fatal chromosomal chaos. But with 53BP1 out of the way, the cells are able to resume homologous recombination. That might explain why cells that lack BRCA1 and eliminate 53BP1 can withstand traditional chemotherapy compounds and PARP inhibitors, a new generation of anti-cancer drugs that are in clinical trials. But how do cancer cells turn down 53BP1?

Researchers previously found that certain mutant fibroblasts increase production of cathepsin L, a protease that destroys 53BP1. BRCA1-deficient cancer cells take advantage of the same mechanism, according to a team of researchers led by Susana Gonzalo from the Washington University School of Medicine. When they cultured breast cancer cells that were missing BRCA1, the cells stopped growing. After two weeks of lethargy, however, some cells, which the researchers dubbed BOGA cells (BRCA1-deficient cells that overcome growth arrest), began to divide again. These cells showed increased levels of cathepsin L and reduced amounts of 53BP1. Eliminating cathepsin L from BOGA cells or dosing them with vitamin D, a cathepsin L inhibitor, prevented the decline in 53BP1 abundance.

To find out whether boosting cathepsin L levels enabled the cancer cells to restart homologous recombination, the researchers monitored sites of DNA damage tagged by RAD51, a protein that helps promote homologous recombination. The cells that had stopped growing did not display RAD51 foci, but these foci were prevalent in BOGA cells with reduced 53BP1. Removing cathepsin L from BOGA cells increased 53BP1 levels and diminished the number of RAD51 foci.

If cells can't perform homologous recombination, they turn to repair mechanisms such as NHEJ that can lead to jumbled chromosomes. However, after DNA-breaking doses of radiation, BOGA cells exhibited few chromosome defects. The number of these flaws climbed after the researchers stabilized 53BP1 levels by inhibiting cathepsin L or trimming its abundance.

The team then analyzed tumor samples from breast cancer patients. Researchers suspect that cathepsin L attacks 53BP1 by entering the nucleus. Samples from patients with BRCA1 mutations or with triple-negative breast cancer -- an aggressive form of the disease -- showed high levels of nuclear cathepsin L and reduced quantities of 53BP1. That suggests tumors in these patients hike the amounts of cathepsin L in the nucleus to break down 53BP1 and restore homologous recombination.

"It's a new pathway that explains how breast cancer cells lose 53BP1," says Gonzalo. How cancer cells boost nuclear cathepsin L levels is unclear, she notes.

Triple-negative breast cancers are currently identified by their lack of Her2 and the estrogen and progesterone receptors. The work suggests that another trio of measurements -- the amounts of 53BP1, cathepsin L, and vitamin D receptor in the nucleus -- might help identify patients that are resistant to current breast cancer treatments. These people might respond to cathepsin inhibitors, some of which are undergoing animal testing. These compounds might steer the cells away from homologous recombination and leave them vulnerable to other therapies.

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The above story is reprinted from materials provided by Rockefeller University Press, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D. A. Grotsky, I. Gonzalez-Suarez, A. Novell, M. A. Neumann, S. C. Yaddanapudi, M. Croke, M. Martinez-Alonso, A. B. Redwood, S. Ortega-Martinez, Z. Feng, E. Lerma, T. Ramon y Cajal, J. Zhang, X. Matias-Guiu, A. Dusso, S. Gonzalo. BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. The Journal of Cell Biology, 2013; 200 (2): 187 DOI: 10.1083/jcb.201204053

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/yzxjZotL_ng/130121122940.htm

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StarStruck: Celebrities Join Wine and Spirits Brands In Growing ...

Celebrity endorsement of wine and spirits is not exactly new. Orson Welles famously assured TV viewers back in 1980 that Paul Masson would ?sell no wine before its time.? But the past decade has seen significant shifts both in the frequency of celebrities aligning with wine and spirits brands and in the nature of the endorsement. Some are spokespersons, some are brand owners, some have licensed their names and images. Some appear in ads or at promotional events, radiated online.

In general, celebrity-brand relationships have become more of a two-way street?not to mention one with more lanes. As more celebrities want in to this relatively glamorous world, more wine and spirits marketers appear eager happy to bring them along for the ride.

The Power of Personality (& Credibility)

Few celeb-brand connections have proven as effective as P. Diddy (Sean Combs) and C?roc. Annual sales of the vodka hovered around 120,000 cases when Combs came on board in 2007; now it?s a million-case brand, with much of the success is attributed to the artist himself appearing in TV ads and the well-known entertainer promoting the brand actively via appearances, both formal and informal.

P. Diddy?s success came with a young brand. Stars can bring juice to established ones as well. Tanqueray Gin partnered with actor and DJ Idris Elba in 2011 for ?Tonight We Tanqueray,? a platform that included events, videos, a downloadable song and even new drink recipes. ?We were looking for partners who could bring to life the style and sophistication of Tanqueray,? says Brand Director Matt Pechman for Tanqueray. ?Idris was a perfect match.?

Before launching a celebrity brand or partnering with a celebrity there are a few considerations, says Dave Karraker, director of public relations for Campari America. ?First we look at the celebrities themselves?who is their demographic and does that demographic match a hole in our portfolio that we have to fill?? he says. Just as important: ?The person has to have credibility to be associated with that spirit.?

Campari recently showcased Oscar-winning actress Penelope Cruz in an evocative 2013 calendar. Entitled ?Kiss Superstition Goodbye,? the calendar shows Cruz indulging in superstitious acts?breaking mirrors, walking under ladders, opening umbrellas indoors, etc.?all while looking fabulous in Campari-red outfits and holding Campari-based cocktails. The calendar project, shot in Milan this year by fashion photographer Kristian Schuller, has been done annually by Campari for more than a decade.

And, naturally, celebrity power is increasingly being tapped for new product launches. One recent example is LeSutra. Grammy-winning producer Timbaland is an owner of the line of sparkling liqueurs, and his high-profile support is intended to draw some of the attention going to rival brand Nuvo, whose rapper-backers include T-Pain, Jeremih, Wale, Pusha T and Lloyd Banks.

In a blend of established brand and new product, Usher was a partner for the launch of Belvedere RED in 2011. Similarly, R&B crooner Ne-Yo helped launch Malibu Red?a fusion of rum and tequila; the collaboration included a custom song and video, supported by social media.

Tapping the Fan Base

Celebrity endorsements can be as much about targeting a specific fan base as they are about publicizing the liquid in the bottle. Star power may be just the right thing to draw attention to both a category and a brand. For instance, when Bacardi launched the Bacardi Light ready-to-serve cocktails, they collaborated with actress Busy Philipps, aiming to attract her vibrant and loyal female following. And Jim Beam Bourbon tapped into the passionate fan base of live music by sponsoring a series of six concerts in 2012 (Kid Rock, Daughtry, David Gray, Darius Rucker, Bush and Train). In addition, Beam collaborated with Kid Rock on several projects, raising funds for Operation Homefront, which provides support for families of American troops.

TY KU Sak? has taken aim at multiple audiences, enlisting diverse support from Bravo?s ?Millioinaire Matchmaker,? Patti Stanger; Intenet gossipmonger Perez Hilton; and well-known singer and The Voice judge CeeLo Green. ?The perception of sak? is that you can only drink it in certain locations or specific ways,? says brand co-owner CeeLo. ?It?s my mission to show how sak? is a progressive cocktail for the modern trendsetter. It?s versatile, low calorie, all natural, accessible and will make you stand out at a party.?

Vodka as a category needs no introduction to Americans, but in aiming to increase their share of the low-calorie segment of the the vodka pie, marketers of Voli brought both Fergie and Pitbull on board. Erin Harris, EVP of marketing and public relations for Voli Spirits, notes that Fergie and Pitbull each bring something different to the table: ?Fergie?who stays fit and owns the social scene?knows how to balance all aspects of life and represents the Voli brand perfectly,? says Harris. ?Pitbull, with his charisma and musical sense, is a force within the Latin market and has a large female demographic.?

Perhaps a taste of more to come, ad campaigns featuring multiple celebs have picked up just within the past year. Hennessy?s ?Wild Rabbit? campaign features Martin Scorsese, Erykah Badu and Manny Pacquiao. Each person?s ?wild rabbit? is what inspires them, keeps them motivated and drives them. The campaign consists of print ads, billboards, installations, QR codes and Web marketing. Johnnie Walker?s ?My Label is Black? is both an ad campaign and outreach program designed to celebrate the Hispanic community and inspire men to achieve their true potential. The ads feature Don Omar, Jorge Posada and Alex Sensation; events and charitable partnerships are set in key markets such as New York, Miami and Los Angeles.

No Cookie-Cutter Molds

To put the recent explosion of celebrity wine/spirits endorsement in perspective, it is important to realize that there are no standard formulas for how the star-brand relationship will be defined or promoted. The degree of involvement can range from select promotional appearances?such as Kim Kardashian hosting a Halloween party for Midori?to full-blown ownership. Some bottles are designed by the stars themselves; others don?t even mention them. But if there is one commonality, it?s that marketers are taking cues from what made the stars stars when considering how best generate publicity.

Musician Dave Matthews has (quite quietly) owned Blenheim Vineyards in Virginia since 2000 and recently worked with Constellation Brands to create The Dreaming Tree wines with winemaker Steve Reeder. ?As part of our 2011 launch strategy, we targeted loyal fans of Dave Matthews, who include consumers ranging from 30-50 years old,? says Sarah Pearson, marketing manager for the brand. ?We felt this grassroots approach was in line with how Dave Matthews rose to popularity and was a great way to honor the fans. After serving his fans first, the wines were made available everywhere.?

One recent collaboration to watch is Enrique Iglesias with Atlantico Rum. Aleco Azqueta, who launched the line in 2008 with partner Brandon Lieb, explains that the new business relationship was entirely organic: Enrique loved the rum before he even met the founders. Azqueta notes, ?A lot of brands developed for a celebrity are gimmicky. This one started with a product that had already won awards and gained respect.? The partnership works, he says, because of its authenticity: ?Atlantico is a lifestyle brand that celebrates Carribean sophistication?and that?s his brand, too.? The Spanish singer-songwriter has given the brand mass exposure through placement in his videos and live concerts.

Passion Plays

The example of Enrique Iglesias and Atlantico highlights the reality that the more hands-on a star is, the more leverage a brand gains in the market. Actor Dan Aykroyd has teamed up with winegrowers in his native Canada to create a line of varietal Niagara wines, but here in the U.S. he invests time and sweat into Crystal Head Vodka, a brand he launched in 2008. ?He is involved in every major decision and also a number of smaller decisions, whether it is production, sales or marketing,? says Kristina Arnold, marketing manager for Crystal Head.

Hands-on tequila-making success stories include rocker Sammy Hagar (Cabo Wabo) and singer-actor Justin Timberlake (901); and country music?s Toby Keith, who created Wild Shot Mezcal. To create 901 (the brand name is based on the Memphis telephone area code), Timberlake and co-owner Kevin Ruder scouted distilleries in Mexico and helped develop the flavor profile. Carlos Santana is now a brand owner of Casa Noble Tequila, and his album covers are featured in packaging. Tequila has also served as insipiration for some high-profile advertising, notably Lollapalooza founder Perry Farrell for Dobel and The Sopranos? Michael Imperioli for 1800. The newest Hollywood kid on the agave block is actor George Clooney, who developed Casamigos Tequila with nightclub maven Rande Gerber (husband of Cindy Crawford).

Hollywood & Vine

On the wine side, Francis Ford Coppola set the gold standard of passion-turned-product. Some might even argue that his wine renown rivals his film legacy. Coppola has plenty of star-powered company when it comes to the fruit of the vine. Down in Santa Barbara, Fess Parker in 1987 established a successful family-run winery more than a decade after starring on TV as Davy Crockett and Daniel Boone. The Smothers Brothers make serious reds at Remick Ridge in Sonoma Valley. Actor Danny Glover is also a grower in Sonoma. TV star Adrian Grenier and film producer Peter Glatzer help blend their Paso Robles red, SHFT, marketed by Domaine Select.

Actor Sam Neill owns Two Paddocks estate winery in Central Otago, New Zealand. Italy?s Bocelli family, known worldwide for the opera success of tenor Andrea, has actually been making wine in Tuscany for more than a century; their wines just recently debuted in the U.S. Italy was also the origin for an eponymous line of wines by Oscar-nominated actress Lorraine Bracco. And Ben Flajnik, perhaps better known as The Bachelor, turned the celebrity-wine formula inside-out?he and two partners created Envolve in Sonoma before he became a reality TV heart-throb.

So many celebrities have gotten into the wine/spirits act that it has become hard to? keep track. M?tley Cr?e frontman Vince Neil has produced wine (Vince Vineyards) as well as Tatuado Tequila and Vodka. Other bands/musicians going the wine route include Mick Fleetwood, Kiss, Bob Dylan (Planet Waves), Simply Red?s Mick Hucknall (Il Cantante), Lil Jon (Little Jonathan), Tool?s Maynard James Keenan (Caduceus), Train (Save Me, San Francisco), even Elvis Presley and Jerry Garcia.

Celebrity fashion icons are tossing their hats into the wine or spirits ring, too. And why not? Great-looking bottles will never go out of style. Jean-Paul Gaultier designed a ?corset? bottle for Piper-Heidsieck. Gianfranco Ferr? dressed up Frescobaldi Brunello for the Millennium. Christian Audigier licensed his tattoo-esque Ed Hardy brand for a line of wine. Roberto Cavalli now has his own vodka. And John Varvatos designed a special bottle stopper for Patr?n Tequila.

Of course, no roundup of celebrity wine would be complete without mention of Marilyn Monroe, whose iconic beauty and fortuitous adopted surname posthumouosly made Marilyn Merlot a fan-driven collectible. Will there ever be another? Probably not. But Hollywood stars now seem more inclined than ever to test their wine chops. Witness Drew Barrymore and Fergie. Both are acutely cognizant that their names needed to be part of the package, literally. The red blend from Ferguson Crest is called ?Fergalicious.? And Drew?s first wine, a Pinot Grigio from northern Italy, features the Barrymore family crest on the label.

Real House-Wines?

real Housewives of New Yorkstar Bethenny Frankel struck gold with her Skinnygirl ready-to-serve cocktails. She sold to Beam Global in 2010 and the brand has since expanded way beyond the original low-cal margarita. Now, branded wines/spirits seem practically contagious among the TV housewives.

In the case of Frankel?s RHONY costar Ramona Singer, her relationship with a type of wine preceded her connection to a brand. The transition was quite natural, explains Claudia Cogan, brand manager at Opici Wine Company. ?Ramona Singer became synonymous with Pinot Grigio, regularly seen sipping it on the show,? says Cogan. ?Fans would approach her asking if she preferred a specific one, but she never really had an answer. She saw this opportunity and seized it, coming to Opici with a proposal.?

Over in New Jersey, Teresa Guidice launched Fabellini, a pre-mixed Bellini in two flavors; and Kathy Wakile launched Red Velvet Cosmo, a pre-mixed cosmopolitan based on the flavors in red velvet cake. Down in Atlanta, three Real Housewives have gone mad for Moscato: NeNe Leakes (Miss Moscato), Cynthia Bailey (P.T. Ros? Moscato) and Kim Zolciak (Viva Diva Moscato). In LA, Vicki Gunvalson and Tamra Barney went a different route, starting a wine club, ?Wines by Wives.?

Will these housewives put up numbers approaching Skinnygirl? Maybe not, but they can be solid sellers. With a Pinot Grigio released in 2011 and red blend in 2012, Ramona has become a 15,000- case brand, distributed nationally.

Selling Star Power

So, now that the wine and spirits industry is getting accustomed to the idea of celebrity endorsement in multiple categories, the question becomes how best to translate star power into sales. Here are some points to keep in mind:

Know what?s what even if you don?t know who?s who. Celebrity culture is powerful but not universal. Different generations, different ethnicities and different interests determine which ?stars? sparkle for different individuals. While it makes little sense to stock every available celebri-brand, it is imperative that when you do, the whole staff should be aware of the relevant connection (because it?s not always on the bottle).

Signage can help move product. Some marketers are ready and able to support celebrity-linked brands with POS material (ask your distributor). If not, especially in cases where the star behind the liquid is not apparent, you can and should create your own signage. It may help spur impulse sales among shoppers who are fans of certain stars/genres but were unaware of the links.

Eye candy is still important. Some bottles act like stars in their own right. For example, bottles of Patr?n Tequila featuring the guitar head bottle stopper designed by menswear mogul John Varvatos are just screaming to be displayed. Catchy bottles in a front window can grab the eye of folks who may not necessarily want that wine or spirit, but will be enticed inside by the display.

Source: http://www.beveragemedia.com/index.php/2013/01/starstruck-celebrities-join-wine-and-spirits-brands-in-growing-numbers-and-unusual-ways/

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Monday, January 21, 2013

Merkel risks election-year setback in state vote

German Chancellor Angela Merkel looks up after smelling at coffee beans during the opening tour of the 'International Green Week' in?Berlin, Germany, Friday, Jan. 18, 2013. International Green Week opens to the public from Jan. 18 until Jan. 27, 2013. (AP Photo/dpa, Michael Kappeler)

German Chancellor Angela Merkel looks up after smelling at coffee beans during the opening tour of the 'International Green Week' in?Berlin, Germany, Friday, Jan. 18, 2013. International Green Week opens to the public from Jan. 18 until Jan. 27, 2013. (AP Photo/dpa, Michael Kappeler)

(AP) ? A major state election on Sunday could shake up the campaign for Germany's national election later this year, with the center-left opposition hoping for a morale-boosting victory over Chancellor Angela Merkel's governing coalition.

Some 6.1 million people are eligible to vote for a new state legislature in Lower Saxony, which occupies a swathe of northwestern Germany. It's been run for the past decade by a coalition of Merkel's conservative Christian Democrats and the pro-market Free Democrats, the same parties that form the national government.

The vote is a significant electoral test before national parliamentary elections in September, in which Merkel will seek a third four-year term. She and her party are riding high in polls, but the opposition hopes Lower Saxony will show she is vulnerable.

Pre-election polls in the state showed a neck-and-neck race between her coalition and the opposition Social Democrats and Greens, who have been struggling to gain traction nationally.

Much could depend on the performance of Merkel's allies, the Free Democrats, whose support has eroded badly since they joined her national government in 2009. They've failed to win major tax cuts that they once pledged and have taken much of the blame for frequent public bickering in the chancellor's coalition.

If the Free Democrats fail to win the 5 percent support needed to gain seats in the state legislature Sunday, that could help hand Lower Saxony to the opposition ? and prompt the departure of embattled party leader Philipp Roesler, who is also vice chancellor.

The opposition leader in Lower Saxony, Stephan Weil, says a win would "fire up" his Social Democrats and would mean that a center-left German government "will be taken seriously as an option after the national election."

The incumbent state governor, popular Christian Democrat David McAllister, says that now "is not the time for any experiments."

Both nationally and in Lower Saxony, Merkel and her party have been bolstered by a relatively robust economy, low unemployment and the chancellor's hard-nosed handling of Europe's debt crisis ? criticized in debt-burdened European countries but well-received among German taxpayers.

Merkel has also profited from stumbles by the Social Democrats' candidate for chancellor, Peer Steinbrueck, a former finance minister whose personal popularity lags far behind Merkel's.

Over recent weeks, Steinbrueck has drawn criticism for saying the chancellor earns too little ? adding to controversy over his own high earnings from the public-speaking circuit.

That hasn't helped a campaign which promises to narrow the gap between Germany's haves and have-nots.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-01-20-Germany-Election/id-bc51e0def828490b949d8a334f450688

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Musial was 'most beloved' Cardinal

'Stan the Man' was 3-time MVP; hitting standout helped Cardinals win 3 World Series titles

Image: Stan MusialAP

Stan Musial was so revered in St. Louis, two statues of him stand outside Busch Stadium.

By R.B. FALLSTROM

updated 2:27 a.m. ET Jan. 20, 2013

ST. LOUIS - No last name necessary.

A slew of batting titles. Corkscrew stance. Humble. A gentleman. All-around good guy.

Stan the Man.

Stanley Frank Musial, the St. Louis Cardinals star who was one of the greatest players in the history of baseball, died Saturday. He was 92.

"I never heard anybody say a bad word about him - ever," Willie Mays said in a statement released by the Hall of Fame.

The Cardinals announced Musial's death in a news release and said he died at his home in Ladue, a St. Louis suburb, surrounded by family. The team said Musial's son-in-law, Dave Edmonds, informed the club of the slugger's death.

Earlier Saturday, baseball lost another Hall of Famer when longtime Baltimore Orioles manager Earl Weaver died at age 82.

Musial, the Midwest icon with too many batting records to fit on his Hall of Fame plaque, was so revered in St. Louis that two statues in his honor stand outside Busch Stadium - one just wouldn't do him justice. He was one of baseball's greatest hitters, every bit the equal of Ted Williams and Joe DiMaggio even without the bright lights of the big city.

Musial won seven National League batting crowns, was a three-time MVP and helped the Cardinals capture three World Series championships in the 1940s.

He spent his entire 22-year career with the Cardinals and made the All-Star team 24 times - baseball held two All-Star games each summer for a few seasons. He had been the longest-tenured living Hall of Famer.

"Stan will be remembered in baseball annals as one of the pillars of our game," Hall of Fame President Jeff Idelson said. "The mold broke with Stan. There will never be another like him."

A pitcher in the low minors until he injured his arm, Musial turned to playing the outfield and first base. It was a stroke of luck for him, as he went on to hit .331 with 475 home runs before retiring in 1963.

Widely considered the greatest Cardinals player ever, Musial was the first person in team history to have his number retired. Ol' 6 probably was the most popular, too, especially after Albert Pujols skipped town.

"I will cherish my friendship with Stan for as long as I live," Pujols wrote on Twitter. "Rest in Peace."

At the suggestion of a pal, actor John Wayne, Musial carried around autographed cards of himself to give away. He enjoyed doing magic tricks for kids and was fond of pulling out a harmonica to entertain crowds with a favorite, "The Wabash Cannonball."

Scandal-free and eager to play every day, Musial struck a chord with fans throughout America's heartland and beyond. For much of his career, St. Louis was the most western outpost in the majors, and the Cardinals' vast radio network spread word about him in all directions.

Farmers in the field and families on the porch would tune in, as did a future president - Bill Clinton recalled doing his homework listening to Musial's exploits.

"We have lost the most beloved member of the Cardinals family," team chairman William DeWitt Jr. said.

Musial's public appearances dwindled in recent years, though he took part in the pregame festivities at Busch Stadium during the 2011 postseason as the Cardinals won the World Series. And he was at the White House in February 2011 when President Barack Obama presented him with the Presidential Medal of Freedom, America's highest civilian honor for contributions to society.

At the ceremony, President Obama said: "Stan remains to this day an icon untarnished, a beloved pillar of the community, a gentleman you'd want your kids to emulate."

He certainly delivered at the plate.

Musial never struck out 50 times in a season. He led the NL in most every hitting category for at least one year, except homers. He hit a career-high 39 home runs in 1948, falling one short of winning the Triple Crown.

"Major League Baseball has lost one of its true legends in Stan Musial, a Hall of Famer in every sense and a man who led a great American life. He was the heart and soul of the historic St. Louis Cardinals franchise for generations," Commissioner Bud Selig said. "As remarkable as `Stan the Man' was on the field, he was a true gentleman in life. All of Major League Baseball mourns his passing."

In all, Musial held 55 records when he retired in 1963. Fittingly, the accolades on his bronze Hall plaque start off with this fact, rather than flowery prose: "Holds many National League records ..."

He played nearly until his 43rd birthday, adding to his totals. He got a hit with his final swing, sending an RBI single past Cincinnati's rookie second baseman - that was Pete Rose, who would break Musial's league hit record of 3,630 some 18 years later.

Of those hits, Musial got exactly 1,815 at home and exactly 1,815 on the road. He also finished with 1,951 RBIs and scored 1,949 runs.

All that balance despite a most unorthodox left-handed stance. Legs and knees close together, he would cock the bat near his ear and twist his body away from the pitcher. When the ball came, he uncoiled.

Unusual, that aspect of Musial.

Asked to describe the habits that kept him in baseball for so long, Musial once said: "Get eight hours of sleep regularly. Keep your weight down, run a mile a day. If you must smoke, try light cigars. They cut down on inhaling."

One last thing, he said: "Make it a point to bat .300."

As for how he did that, Musial offered a secret.

"I consciously memorized the speed at which every pitcher in the league threw his fastball, curve, and slider," he said. "Then, I'd pick up the speed of the ball in the first 30 feet of its flight and knew how it would move once it has crossed the plate."

It worked pretty well, considering Musial began his baseball career as a pitcher in the low minors. And by his account, as he said during his induction speech in Cooperstown, an injury had left him as a "dead, left-handed pitcher just out of Class D."

Hoping to still reach the majors, he turned to another position. It was just the change he needed.

Musial made his major league debut late in 1941, the season that Williams batted .406 for the Boston Red Sox and DiMaggio hit in a record 56 straight games for the New York Yankees.

Musial never expressed regret or remorse that he didn't attract more attention than the cool DiMaggio or prickly Williams. Fact is, Musial was plenty familiar in every place he played.

Few could bring themselves to boo baseball's nicest superstar, not even the Brooklyn Dodgers crowds that helped give him his nickname, a sign of weary respect for his .359 batting average at Ebbets Field.

Many, many years before any sports fans yelled "You're the man!" at their favorite athletes, Stan was indeed the Man.

Dodgers pitcher Preacher Roe once joked about how to handle Musial: "I throw him four wide ones and then I try to pick him off first base."

Brooklynites had another reason to think well of Musial: Unlike Enos Slaughter and other Cardinals teammates, he was supportive when the Dodgers' Jackie Robinson broke baseball's color barrier in 1947. Bob Gibson, who started out with the Cardinals in the late 1950s, would recall how Musial had helped establish a warm atmosphere between blacks and whites on the team.

"I knew Stan very well," Mays said. "He used to take care of me at All-Star games, 24 of them. He was a true gentleman who understood the race thing and did all he could."

Like DiMaggio and Williams, Musial embodied a time when the greats stayed with one team. He joined the Cardinals during the last remnants of the Gas House Gang and stayed in St. Louis until Gibson and Curt Flood ushered in a new era of greatness.

"Sad to hear about Stan the Man, it's an honor to wear the same uniform," current Cardinals slugger Matt Holliday tweeted.


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Sunday, January 20, 2013

Warmer soils release additional CO2 into atmosphere; Effect stabilizes over longer term

Jan. 20, 2013 ? Warmer temperatures due to climate change could cause soils to release additional carbon into the atmosphere, thereby enhancing climate change - but that effect diminishes over the long term, finds a new study in the journal Nature Climate Change. The study, from UNH professor Serita Frey and co-authors from the University of California-Davis and the Marine Biological Laboratory, sheds new light on how soil microorganisms respond to temperature and could improve predictions of how climate warming will affect the carbon dioxide flux from soils.

The activities of soil microorganisms release 10 times the carbon dioxide that human activities do on a yearly basis. Historically, this release of carbon dioxide has been kept in check by plants' uptake of the gas from the atmosphere. However, human activities are potentially upsetting this balance.

Frey and co-authors Johan Six and Juhwan Lee of UC-Davis and Jerry Melillo of the Marine Biological Laboratory were curious how increased temperatures due to climate change might alter the amount of carbon released from soils. "While they're low on the charisma scale, soil microorganisms are so critically important to the carbon balance of the atmosphere," Frey says.

"If we warm the soil due to climate warming, are we going to fundamentally alter the flux of carbon into the atmosphere in a way that is going to feed back to enhance climate change?"

Yes, the researchers found. And no.

The study examined the efficiency of soil organisms - how completely they utilize food sources to maintain their cellular machinery - depending upon the food source and the temperature under two different scenarios. In the first short-term scenario, these researchers found that warming temperatures had little effect on soils' ability to use glucose, a simple food source released from the roots of plants. For phenol, a more complex food source common in decomposing wood or leaves, soils showed a 60 percent drop in efficiency at higher temperatures.

"As you increase temperature, you decrease the efficiency - soil microorganisms release more carbon dioxide to the atmosphere - but only for the more complex food sources," Frey explains. "You could infer that as the soil warms, more carbon dioxide will be released into the atmosphere, exacerbating the climate problem."

That effect diminishes, however, in the second scenario, in which soils were warmed to 5 degrees Celsius above the ambient temperature for 18 years. "When the soil was heated to simulate climate warming, we saw a change in the community to be more efficient in the longer term," Frey says, lessening the amount of carbon dioxide the soils release into the atmosphere and, in turn, their impact on the climate. "The positive feedback response may not be as strong as we originally predicted."

The research team also examined how changes in soil microorganism efficiency might influence long term storage of carbon in soils as predicted by a commonly used ecosystem model. Models of this type are used to simulate ecosystem carbon dynamics in response to different perturbations, such as land-use change and climate warming. These models generally assume that efficiency is fixed and that it does not change with temperature or other environmental conditions. The team found a large effect on long-term soil carbon storage as predicted by the model when they varied carbon use efficiency in a fashion comparable to what they observed in their experiments. "There is clearly a need for new models that incorporate an efficiency parameter that is allowed to fluctuate in response to temperature and other environmental variables," Six says.

The researchers hypothesize that long-term warming may change the community of soil microorganisms so that it becomes more efficient. Organism adaptation, change in the species that comprise the soils, and/or changes in the availability of various nutrients could result in this increased efficiency.

This study was based on work done at the Harvard Forest Long-Term Ecological Research site in Petersham, Mass., where Frey and Melillo have been warming two sites - one 9 meters square, the other 36 meters square -- with underground cables for two versus 18 years. "It's like having a heating blanket under the forest floor," Frey says, "allowing us to examine how this particular environmental change -- long-term soil warming -- is altering how the soil functions."

This work was supported by an NSF Faculty Early Career Development Award, the NSF Long-term Ecological Research (LTER) Program, a DOE National Institute for Climatic Change Research (NICCR) grant, and a Harvard Forest Bullard Fellowship to Frey.

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The above story is reprinted from materials provided by University of New Hampshire. The original article was written by Beth Potier.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Serita D. Frey, Juhwan Lee, Jerry M. Melillo, Johan Six. The temperature response of soil microbial efficiency and its feedback to climate. Nature Climate Change, 2013; DOI: 10.1038/NCLIMATE1796

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/9gjzRphqMlw/130120150029.htm

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